There are many definitions of aging and none of them can capture its complexity, as many do not use the integration of complex systems, but try to capture aging as a single reductionist phenomenon relying on unidirectional pathway. Aging is a very complex process either from the biological or from the social/psychological point of view. Finally, it showed the way towards potential multimodal interventions involving a holistic approach to optimize the aging process towards a healthy longevity.Īging is one of the most mysterious human experiences which always fascinated researchers, philosophers, and artists. It has also opened the way to add new concepts to the original one, leading to better understanding of the nature of inflammaging and of aging itself. Thus, this conceptualization opens the way to consider age-related processes in their complexity, meaning that not only the process but also all counter-processes should be considered. The concept of inflammaging has also revealed the complex, systemic nature of aging. Depending on which way prevails in an individual, the outcome may be healthy longevity or pathological aging burdened with aging-related diseases. This dichotomy is influenced by both the genetics and the environment. This conceptualization permitted to consider the lifelong proinflammatory process as an adaptation which could eventually lead to either beneficial or detrimental consequences. This was an evolutionary or rather a revolutionary conceptualization of the immune changes in response to a lifelong stress. The inflammaging concept was introduced in 2000 by Prof.

Norma optical pathological aging